Use | intermediate for ibuprofen. |
production method | toluene is hydrocarbonized with propylene in the presence of metal potassium, sodium carbonate and graphite to generate isobutylbenzene, then 4-isobutylacetophenone was condensed with acetyl chloride under the catalysis of anhydrous aluminum trichloride, and the latter was condensed with ethyl chloroacetate under the action of sodium isopropoxide to give 3-(4-isobutylphenyl)-2,3-epoxy butyric acid ethyl ester, and then with sodium hydroxide hydrolysis to prepare the product. |